{"id":744292,"date":"2022-12-22T17:52:06","date_gmt":"2022-12-22T21:52:06","guid":{"rendered":"https:\/\/spaceweekly.com\/?p=744292"},"modified":"2022-12-22T17:52:06","modified_gmt":"2022-12-22T21:52:06","slug":"researchers-discover-humpty-dumpty-water-based-mechanism-of-human-sex-reversal-at-edge-of-developmental-ambiguity","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=744292","title":{"rendered":"Researchers discover &#039;Humpty-Dumpty&#039; water-based mechanism of human sex reversal at edge of developmental ambiguity"},"content":{"rendered":"<p>Researchers from Indiana University School of Medicine have discovered a molecular &#8220;clamping&#8221; mechanism within a male-specific protein-DNA complex whose mutation causes sex reversal: children with XY chromosomes but female bodies, a condition called Swyer Syndrome. The clamp exploits a water molecule bridging the male factor (designated SRY) and DNA control sites at the tenuous beginnings of male development.&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\n Click here for original story, <a href=\"https:\/\/phys.org\/news\/2022-12-humpty-dumpty-water-based-mechanism-human-sex.html\" target=\"_blank\" rel=\"nofollow noopener\">Researchers discover &#8216;Humpty-Dumpty&#8217; water-based mechanism of human sex reversal at edge of developmental ambiguity<\/a>&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\nSource: Phys.org&#013;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from Indiana University School of Medicine have discovered a molecular &#8220;clamping&#8221; mechanism within a male-specific protein-DNA complex whose mutation causes sex reversal: children with XY chromosomes but female bodies,&hellip; <\/p>\n","protected":false},"author":1,"featured_media":615444,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-744292","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phys-org"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/744292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=744292"}],"version-history":[{"count":0,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/744292\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=744292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=744292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=744292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}