{"id":751023,"date":"2023-03-20T14:33:15","date_gmt":"2023-03-20T18:33:15","guid":{"rendered":"http:\/\/spaceweekly.com\/?p=751023"},"modified":"2023-03-20T14:33:15","modified_gmt":"2023-03-20T18:33:15","slug":"researchers-identify-key-source-of-t-cell-exhaustion","status":"publish","type":"post","link":"https:\/\/spaceweekly.com\/?p=751023","title":{"rendered":"Researchers identify key source of T cell &#039;exhaustion&#039;"},"content":{"rendered":"<p>Scientists show the commanding role of a specialized group of proteins in the nuclei of our cells, called mSWI\/SNF (or BAF) complexes, both in activating T cells to attack cancer and triggering exhaustion. The discovery suggests that targeting certain of these complexes, either by gene-cutting technologies such as CRISPR or with targeted drugs, could reduce T cell exhaustion and give CAR T cells (and in general, all tumor-fighting T cells) the staying power to take on cancer.&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\n Click here for original story, <a href=\"https:\/\/www.sciencedaily.com\/releases\/2023\/03\/230320143315.htm\" target=\"_blank\" rel=\"nofollow noopener\">Researchers identify key source of T cell &#8216;exhaustion&#8217;<\/a>&#013;<br \/>\n&#013;<br \/>\n&#013;<br \/>\nSource: ScienceDaily&#013;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists show the commanding role of a specialized group of proteins in the nuclei of our cells, called mSWI\/SNF (or BAF) complexes, both in activating T cells to attack cancer&hellip; <\/p>\n","protected":false},"author":1,"featured_media":615444,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-751023","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genaero"],"_links":{"self":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/751023","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=751023"}],"version-history":[{"count":0,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/posts\/751023\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=\/wp\/v2\/media\/615444"}],"wp:attachment":[{"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=751023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=751023"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/spaceweekly.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=751023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}