A research team led by scientists at Brigham and Women’s Hospital has assembled a catalogue of every active gene in a variety of tissues in the axolotl, a type of salamander known for its striking ability to fully regenerate limbs following amputation. The catalogue, known as a “transcriptome,” provides a important resource for the community of researchers who study axolotls—a model organism that promises to shed light not only on the molecular mechanisms that underlie limb regeneration but also how on potential ways to repair and replace human tissues that are damaged or lost as a result of injury, illness, or even congenital disorders.