Imaging very small materials takes not only great skill on the part of the microscopist, but also great instruments and techniques. For a refined microscopic look at biological materials, the challenges include getting an image that is free from “noise,” the interference that can be caused by a number of items, including the area surrounding an item. Labels, dyes, or stains that are added in order to see the item more clearly can also present issues as they can affect the item that is to be scanned in unexpected ways—damaging or even killing biological materials.