Researchers at Eindhoven University of Technology (TU/e) present a new method for controlled drug delivery into the bloodstream using DNA computers. In the journal Nature Communications, the team, led by biomedical engineer Maarten Merkx, describes how it has developed the first DNA computer capable of detecting several antibodies in the blood and performing subsequent calculations based on this input. This is an important step toward the development of smart drugs for better delivery of medication for conditions such as rheumatism and Crohn’s disease, with fewer side effects and at lower cost.