Cell ‘stickiness’ could indicate metastatic potential

How strongly tumor cells adhere to the surrounding tissue could indicate the likelihood that cancer will spread to other parts of the body, according to a study published February 28 in Biophysical Journal. Using a spinning disc device, the researchers found that tumor cells characterized by weak adhesion strength are more likely to migrate and invade other tissues compared with strongly adherent cells. The study may provide a much-needed marker to identify highly metastatic cells within a broader tumor cell population.