Abstract: In late 2015 early 2016, a major cryo-vacuum test was carried out for the Integrated Science Instrument Module (ISIM) of the James Webb Space Telescope. This test comprised the final cryo-certification and calibration test of the ISIM before its delivery for integration with the rest of the JWST observatory. Over the roughly 100-day period of the round-the-clock test program, the full complement of ISIM flight instruments, structure, harness radiator, and electronics were put through a compre…