Abstract: This paper continues the annual tradition, at this conference, of summarizing the results of chemical analyses performed on archival potable water samples returned from the International Space Station (ISS). 2016 represented a banner year for life aboard the ISS, including the successful conclusion for 2 crewmembers of a record 1-year mission. Water reclaimed from urine and/or humidity condensate remained the primary source of potable water for the crewmembers of ISS Expeditions 46-50. The ye…