A newly described protein could be an effective target for combatting drug-resistant malaria parasites. The protein, the transcription factor PfAP2-I, regulates a number of genes involved with the parasite’s invasion of red blood cells, a critical part of the parasite’s complex life cycle that could be targeted by new antimalarial drugs. A paper describing the protein PfAP2-I and its role in the invasion process appears June 14, 2017 in the journal Cell Host & Microbe.