Inside every cell is a complex infrastructure of organelles carrying out different functions. Organelles must exchange signals and materials to make the cell operate correctly. New technologies are allowing researchers to see and understand the networks that connect these organelles, allowing them to build maps of the trade routes that exist within a cell. A study to be published in the September 29 issue of the Journal of Biological Chemistry reports the use of an emerging method to identify proteins that allows two organelles, the mitochondria and the endoplasmic reticulum, to attach to each other.