Principles for computational design of binding antibodies

The idea of proteins that can be designed on computers for specific functions has been a cutting-edge concept that has stubbornly remained “in the future.” New research at the Weizmann Institute of Science may bring that future a bit closer. By going back to nature’s drawing board – evolution – the scientists have created new proteins, based on “existing natural parts,” that carry out their intended function with flying colors. These findings were reported in the Proceedings of the National Academy of Sciences (PNAS).