Malaria is a parasitic disease transmitted between humans through the bite of the female anopheles mosquito. Endemic in large tropical zones, Plasmodium falciparum kills more than 500’000 people per year, about 80% of which are children under the age of five. Although therapeutic strategies have been implemented for a long time, they have so far remained moderately effective. By identifying two proteases essential for the parasite’s survival and dissemination as well as a molecule capable of inhibiting them, researchers at the Universities of Geneva (UNIGE), Switzerland, and Bern (UNIBE) bring a new hope in the fight against malaria. Their discovery could lead to the development of drugs blocking not only the parasite development in human beings, but also the human to mosquito transmission and vice-versa. These seminal results can be read in Science.