Abstract: Throughout the human space flight program there have been instances where smoke, fire, and pressure loss have occurred onboard space vehicles, putting crews at risk for loss of mission and loss of life. In every instance the mission has been in Low-Earth-Orbit (LEO) with access to multiple volumes that could be used to quickly seal off the damaged module or escape vehicles for a quick return to Earth. For long duration space missions beyond LEO, including Mars transit missions of about 1000 d…