Abstract: Throughout the human space flight program there have been instances where systems failures resulting in smoke, fire, and pressure loss have occurred onboard space vehicles, putting crews at risk for loss of mission and loss of life. In most instances the missions have been in Low-Earth-Orbit (LEO) or Earth-Moon vicinity, with access to multiple volumes that could be used to quickly seal off the damaged module or access escape vehicles for return to Earth. For long duration missions beyond LEO…