Researchers observe the switching of Ras protein in detail

Ras proteins are molecular switches that decide if and when cells divide inside our bodies. An impairment of their function may result in the formation of a tumour. The process of switching the proteins on and off has been observed in detail by a research team headed by Prof Dr. Klaus Gerwert from the Department of Biophysics at Ruhr-Universität Bochum (RUB); using a combination of methods, the team confirmed the hypothesis that the binding partner of Ras in its bonded form does not contain any hydrogen atoms in the phosphate groups. The renowned Journal of Biological Chemistry has published the report as its cover story on March 16, 2018.