What’s the minimum number of people you should send in a generational ship to Proxima Centauri?

Humanity has long dreamed about sending humans to other planets, even before crewed spaceflight became a reality. And with the discovery of thousands exoplanets in recent decades, particularly those that orbit within neighboring star systems (like Proxima b), that dream seems closer than ever to becoming a reality. But of course, a lot of technical challenges need to be overcome before we can hope to mount such a mission.