Optoacoustic imaging powered by short bursts of continuous wave (CW) lasers can stimulate the emission of ultrasound waves inside an animal or in human subjects. The method can noninvasively capture blood flow and produce 3-D images of cellular microarchitecture. Writing in Light: Science & Applications, Stephan Kellnberger and colleagues at the Institute of Biological and Medical Imaging, now report the possibility of obtaining high-fidelity optoacoustic images with cost-effective lasers controlled at multiple frequencies.