Abstract: In our talk we will discuss considerations and best practices for organizing data and metadata in HDF5 files when serving ESDIS products in S3 with OPeNDAP. The first part of the talk will be devoted to the best practices for organizing data and user-defined metadata including CF conventions in HDF5. We will also address interoperability with netCDF-4 and its role in accessing data in HDF5. In the second part of the talk we will go over OPeNDAP considerations for S3 access to HDF5 data.