University of Oklahoma researchers, led by Courtney Hofman and Rita Austin, in collaboration with the Smithsonian National Museum of Natural History, are addressing the challenges of curating ancient biomolecules and working toward the development and dissemination of best practices. In a recent paper published in the Proceedings of the National Academy of Sciences, Hofman and her collaborators suggest museums play a critical role among stakeholders in ancient biomolecules research and should be responsive to these concerns.