Technique uses well-known dye to watch amyloid plaques in the brain

While amyloid plaques have long been closely associated with mechanisms driving Alzheimer’s disease, visualizing how amyloid proteins assemble continues to prove difficult. The nanometer-sized amyloid fibrils are only a fraction of the size that the best light microscopes are able to resolve. New work repurposing one of the oldest known reagents for amyloid looks to help provide a clearer picture of how fibrils come together.