Nature provides lots of antimicrobials. However, given the rapid increase of antimicrobial resistance, there is a need for the development of synthetic antibiotics. Lantibiotics are an interesting option. Molecular biologists from the University of Groningen and their colleagues in Switzerland and Germany have now developed a pipeline to create and screen large numbers of new lantibiotic peptides. A description of the method and the first results were published on 1 April in the journal Nature Chemical Biology.