Stimulating the differentiation of bone precursors with organically modified hydroxyapatite (ormoHAP) nanospheres

Bioinspired materials mimic their natural counterparts for characteristic functionality in multidisciplinary applications forming a popular theme in biomaterials development. In bone tissue engineering, for instance, researchers focus on the natural composite architecture of bone, organically designed from complex structures of mineralized collagen. The resulting bioengineered constructs include inorganic/organic composites based on native mammalian bone components such as carbonated apatite and collagen. However, microparticle incorporation to material constructs can cause complications during premature in vivo resorbability, due to their brittle nature.