Deciphering the mechanism that determines organ size and shape

A study by IRB Barcelona’s Development and Growth Control Laboratory, headed by ICREA researcher Marco Milán, reveals how Dpp and Wg morphogens regulate organ proportions and patterning of the fly wing through independent mechanisms. Given that these morphogens are present in vertebrates, these results are highly significant for understanding the development and growth of human limbs. “The regulatory mechanism that we describe in this study may pave the way to new research lines on malformations and congenital diseases in humans,” says Marco Milán.


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Source: Phys.org