Cholesterol binding sends long-distance communication signals in proteins

Humans with a high cholesterol fear the “bad cholesterol”—the so-called low-density lipoprotein (LDL)—because it is genetic and cannot be regulated with medication. However, a healthy occurrence of LDL is important for cellular processes. LDL takes up cholesterol esters—which contain both cholesterol and fatty acid—in the blood and transports it to the cell. In the vesicular lysosomes of the cell, the ester is broken down by enzymes. The resulting free cholesterol is then transported to other parts of the cell, such as the endoplasmic reticulum and other cell membranes, where it is needed for cell processes. A cholesterol balance (homeostasis) is created in the lysosomes.


Click here for original story, Cholesterol binding sends long-distance communication signals in proteins


Source: Phys.org