Lanthanide-doped nanoparticles (LnNPs) can harvest the near-infrared (NIR) light to emit higher energy photons (upconversion) or lower energy photons (downshifting). In a recent study published in ACS Nano, a team led by Prof. CHANG Yulei from Changchun Institute of Optics, Fine Mechanics and Physics of the Chinese Academy of Sciences developed a novel photoswitchable nanoparticle based on LnNPs for antitumor application, which had UV-blue and NIR-IIb (1525 nm) emission upon 980 nm laser, and 1525 nm emission upon 800 nm laser. The above nanoparticles were further used for achieving real-time NIR-IIb (800 nm) imaging-guided photodynamic therapy (PDT) (980 nm).
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Source: Phys.org