It is not an exaggeration to say that the question of where and when the Black Death, the deadliest pandemic ever, originated is one of the biggest mysteries in human history. After all, the Black Death was the first wave of the second plague pandemic of the 14th to early 19th centuries. It killed some 50–60% of the population in Europe, the Middle East and North Africa and an unaccountable number of people in Central Asia.
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Source: Phys.org