Scientists have learned a lot about human biology by looking at cells under a microscope, but they might not notice tiny differences between cells or even know what they’re looking for. Researchers at the Broad Institute of MIT and Harvard, in the laboratories of Anne Carpenter and Stuart Schreiber, first started developing cell painting 13 years ago to take cell imaging to the next level. The method, further advanced by Carpenter, now senior director of the Broad’s Imaging Platform and senior group leader Shantanu Singh, and colleagues, uses six colored dyes to stain eight different cell organelles. Machine learning models recognize subtle differences in the images—changes in cell morphology that might indicate disease or a drug or genetic perturbation—which allows researchers to predict the effects of a drug or mutation.
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Source: Phys.org