Metabolic diseases, including diabetes, fatty liver, and obesity, have become a major “killer” affecting human health. Studies have shown that some orphan receptors could be targets for the treatment of these diseases. GPR119, also known as glucose-dependent insulinotropic receptor, is an orphan receptor in the G protein-coupled receptor (GPCR) superfamily. Activation of GPR119 can stimulate the secretion of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulin-releasing polypeptide (GIP), two hormones that are important for regulating the balance of glucose metabolism in the body.
Click here for original story, Study reveals ligand recognition mechanism of orphan receptor GPR119
Source: Phys.org