High-voltage cryo-electron microscopy reveals tiny secrets of 'giant' viruses

Despite their name, giant viruses are difficult to visualize in detail. They are too big for conventional electron microscopy, yet too small for optical microscopy used to study larger specimens. Now, for the first time, an international collaboration has revealed the structure of tokyovirus, a giant virus named for the city in which it was discovered in 2016, with the help of cryo-high-voltage electron microscopy.


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Source: Phys.org