ABC transporters constitute a major class of multidrug resistance proteins, e.g., in cancer cells. Membrane lipids have been long known to influence the structure and functional dynamics of these proteins. However, previous structural and biochemical studies on ABCG2 are limited either by their static description or low spatial resolution to provide a microscopic view of the dynamics of the drug binding and lipid interactions.
Click here for original story, Differential dynamics and direct interaction of bound ligands with lipids in multidrug transporter ABCG2
Source: Phys.org