Synthetic mRNAs are explored rigorously for their potential as an effective genetic vector for basic research and clinical applications. Natural mRNAs have a structure on their leading (5′) ends—called the 5′ cap—that regulates their stability and translational activity. As such, there is a tremendous effort to devise new methods to chemically modify and generate functional 5′ cap structures.
Click here for original story, Development of a versatile method to synthesize functional mRNAs with diverse 5′ cap structures
Source: Phys.org