DART VADAR harnesses the force of enzymes for better RNA drugs

Gene therapy has been heralded as the new frontier of medicine, but there are still many limitations to current technologies; among them, how to deliver therapeutic genes to specific cells, and only activate them in the right context. A team has created a new RNA-based tool called DART VADAR to bring gene editing out of the ‘dark side’ of those problems and into the light. Using an engineered form of a naturally occurring enzyme, their sensors can automatically sense the presence of a trigger molecule and initiate the translation of payload genes within cells. The advance broadens the scope of conditions that can be treated with RNA-based therapeutics and enables the development of highly specific treatments for a variety of diseases.


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Source: ScienceDaily