Scientists show the commanding role of a specialized group of proteins in the nuclei of our cells, called mSWI/SNF (or BAF) complexes, both in activating T cells to attack cancer and triggering exhaustion. The discovery suggests that targeting certain of these complexes, either by gene-cutting technologies such as CRISPR or with targeted drugs, could reduce T cell exhaustion and give CAR T cells (and in general, all tumor-fighting T cells) the staying power to take on cancer.
Click here for original story, Researchers identify key source of T cell ‘exhaustion’
Source: ScienceDaily