New 'radar' detects active cellular destroyers

Cells in the human body must adapt their protein balance to certain situations, such as the availability of iron or an infection. These adaptations occur through a complex process in which proteins that are no longer needed or that are toxic are tagged for destruction by attaching a small protein called ubiquitin to them. This marking of a protein for destruction by tagging with ubiquitin is carried out by Cullin-RING Ligases, or “CRLs” for short. Therefore, CRLs can be considered as “destroyers” of specific protein molecules.


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Source: Phys.org