When targeting problem proteins involved in causing or spreading disease, a drug will often clog up a protein’s active site so it can’t function and wreak havoc. New strategies for dealing with these proteins can send these proteins to different types of cellular protein degradation machinery such as a cell’s lysosomes, which act like a protein wood chipper.
Click here for original story, Unlocking pathways to break down problem proteins presents new treatment opportunities
Source: Phys.org