As human diseases become alarmingly antibiotic resistant, identification of new pharmaceuticals is critical. The cane toad and other members of the Bufonidae family produce substances widely used in traditional folk medicine, but endangered family members, like Panama’s golden frog, Atelopus zeteki, may disappear before revealing their secrets. Smithsonian scientists and colleagues at the University of Panama; Panama’s government research center, INDICASAT AIP; Vanderbilt University in Tennessee; and Acharya Nagarjuna University in Guntur, India, created a compendium of the known chemicals produced by this amphibian family in the Journal of Ethnopharmacology, highlighting their largely unexplored potential for new drug discovery.