Heterocyclic compounds are enormously crucial in various industries including food, agricultural, cosmetics and pharmaceuticals. Heterocyclic pharmacophores are one of the main chemical components in drug discovery research. A report in 2013 claims that four out of six and nine out of twenty one highest selling medicines in the world are small molecule heterocyclic compounds. Therefore, easy access of medicinally active heterocycles or drug candidates is essential for a routine structure-activity relationship (SAR) study. Reactions under environmentally benign conditions following green chemistry techniques are a subject of intensive investigation. Microwave-induced rapid synthesis of organic compounds helps to reduce waste formation by reducing unwanted side reactions, maintaining atom economy, and providing products with high yield and, in many instances, with predictable stereochemistry.