Freshwater megafauna such as river dolphins, crocodilians and sturgeons play vital roles in their respective ecosystems. In a recent scientific publication, researchers of the Leibniz-Institute of Freshwater Ecology and Inland Fisheries (IGB) in Berlin have teamed up with international colleagues to illustrate the factors that currently threaten these large vertebrates. The authors also call for a more comprehensive assessment on these large freshwater animals and for a more targeted conservation plan. Also, a wider range of freshwater species and freshwater ecosystems suffering from biodiversity decrease have the potential to benefit from such megafauna-based actions.