All stakeholders in the scientific research enterprise—researchers, institutions, publishers, funders, scientific societies, and federal agencies – should improve their practices and policies to respond to threats to the integrity of research, says a new report from the National Academies of Sciences, Engineering, and Medicine. Actions are needed to ensure the availability of data necessary for reproducing research, clarify authorship standards, protect whistleblowers, and make sure that negative as well as positive research findings are reported, among other steps.