Researchers at the RIKEN Brain Science Institute have determined the atomic resolution structure of a key molecule that translates signals from a cell’s local environment into a language that the cell can understand and use. The determination of the architecture of the Inositol Tris-Phosphate Receptor (IP3R) had long been considered a major goal in biomedical research because of its strategic role inside cells as a molecular train station for transferring signals that control many cell functions.