Main Bus Switching Unit (MBSU) 2 Remove & Replace (R&R): Friday evening and into Saturday, Robotics Ground Controllers maneuvered the Special Purpose Dexterous Manipulator (SPDM) Arms and successfully removed the failed MBSU 2 and replaced it with a spare. The failed MBSU was then installed onto External Stowage Platform (ESP)-2. After a successful power up and checkout of the new MBSU 2, on Sunday the crew removed the Lab Secondary Power Distribution Assembly (SPDA) Jumper and the Lab Truss Contingency Jumper (LTCJ). The jumpers had been in place since last Thursday to ensure that power was maintained to downstream loads during the R&R. Ground Teams have since brought all ISS Systems back to their nominal power configuration. Sarcolab-3: Last Friday the crew configured the Muscle Atrophy Research & Exercise System (MARES) in the Columbus module. Today the crew began the third of three two-day operations of joint-NASA-ESA-Russia Sarcolab experiment. The subject will ingress MARES followed by the operator performing ultrasound measurements of the right calf muscle with remote guidance and direction assistance from ground specialists. The subject will then don Percutaneus Electrical Muscle Stimulator (PEMS) for electrical stimulation at rest and during voluntary muscle contraction, and Electromyography (EMG) electrodes to measure calf muscle and tendon response at the ankle (calf muscle insertion). Myotendinous and Neuromuscular Adaptation to Long-term Spaceflight (Sarcolab) investigates the adaptation and deterioration of the soleus (calf muscle) where it joins the Achilles tendon which links it to the heel and carries loads from the entire body. Muscle fiber samples are taken from crew members before and after flight and analyzed for changes in structural and chemical properties. MRI and ultrasound tests and electrode stimulation are conducted to help assess muscle and tendon changes caused by microgravity exposure. OsteoOmics: The crew began the second of four weeks of planned OsteoOmics operations by changing BioCell media in BioCell Habitat 1. The media in the other four habitats will be changed this week. Crewmembers experience bone loss in orbit stemming from the lack of gravity acting on their bones. OsteoOmics investigates the molecular mechanisms that dictate this bone loss by examining osteoblasts which form bone, and osteoclasts, which dissolve bone. Improved understanding of these mechanisms could lead to more effective countermeasures to prevent bone loss during space missions and in a wide range of disorders on Earth. This may lead to better preventative care or therapeutic treatments for people suffering bone loss as a result of bone diseases like osteopenia and osteoporosis, or for patients on prolonged bed rest. Light Microscopy Module (LMM) Biophysics 3: The crew configured the LMM for the Biophysics science runs in the Fluids Integrated Rack (FIR). The Advanced Colloids Experiment-Temperature-1 (ACE-T-1) Module and the LMM Control Base was removed from the FIR, the LMM objective lenses were configured and the LMM Petri Base was installed. Investigators will use the results from LMM Biophysics 3 to examine the movement of single protein molecules in microgravity. By studying the crystals of a higher quality that can be grown in microgravity, scientists will be able to better understand their structure and how they work. Lighting Effects Meter Reading: The crew set up and configured the Light Meter hardware and took readings in the US Lab and the JEM Pressurized Module (JPM). Both modules use the legacy General Luminaire Assembly (GLA). The Lighting Effects experiment hopes to better quantify and qualify how lighting can effect habitability of spacecraft. The light bulbs on the ISS are being replaced with a new system designed for improved crew health and wellness. The Lighting Effects investigation studies the impact of the change from fluorescent light bulbs to solid-state light-emitting diodes (LEDs) with adjustable intensity and color and aims to determine if the new lights can improve crew circadian rhythms, sleep, and cognitive performance. Results from this investigation also have major implications for people on Earth who use electric lights. Dose Tracker: The crew completed a weekly medication tracking entry in the Dose Tracker application. Dose Tracker documents the medication usage of crewmembers before and during their missions by capturing data regarding medication use during spaceflight, including side effect qualities, frequencies and severities. The investigation is expected to provide anecdotal evidence of medication effectiveness during flight and any unusual side effects experienced. Fine Motor Skills (FMS): The crew completed a series of interactive tasks during a FMS session today. The FMS investigation studies how the fine motor skills are effected by long-term microgravity exposure, different phases of microgravity adaptation, and sensorimotor recovery after returning to Earth gravity. The goal of the investigation is to determine how fine motor performance in microgravity trends/varies over the duration of a six-month and year-long space mission; how fine motor performance on orbit compare with that of a closely matched participant on Earth; and how performance trends/varies before and after gravitational transitions, including periods of early flight adaptation and very early/near immediate post-flight periods. Extravehicular Activity (EVA) Preparations: In preparation for Friday’s planned EXPRESS Pallet Controller Assembly (ExPCA) EVA, the crew configured cameras to be used during the EVA. They also configured required tools and hardware and reviewd a video briefing package followed by a Robotics On-board Training session. Emergency On-Board Training (OBT) Simulator Review: The 49S crew performed this review covering US and Russian Segment fire scenarios as well as depressurization and ammonia emergency scenarios. Today’s Planned Activities All activities were completed unless otherwise noted. PWS1 T61P Software Load Personal Data Prep for Return Fluids Integrated Rack Doors Open Audit of light fixtures in SM, MRM1, MRM2, DC1 [РСПИ]. Delete files from [БЗУ] EKON-M. Observations and photography Extravehicular Activity (EVA) Reminder for On-Orbit Fit check Verification (OFV) Reminder 2 Fine Motor Skills Tropical Cyclone Hardware Closeout Acoustic Dosimeter Setup Day 1 Fine Motor Skills Experiment Test – Subject SM Ventilation Subsystem Preventive Maintenance. Group [В2] MARES Ankle Shaving Preparation Human Research Facility Ultrasound 2 set up and power on Review Emergency OBT Simulator Functionality OsteoOmics Media Relocate Glacier Desiccant Swap Alternate MARES Ultrasound Session Assistance MARES Ultrasound session […]