Research consortium produces high-resolution 3-D map of GLP-1R

An international team led by the iHuman Institute, ShanghaiTech University determined the molecular structure of the human glucagon-like peptide-1 receptor (GLP-1R). The results, described in the paper entitled “Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators,” appears May 17, 2017 in the journal Nature. This study is published together in Nature with a companion paper led by colleagues at the Shanghai Institute of Materia Medica (SIMM) describing the full length glucagon receptor.