As climate change brings new pressures to bear on wildlife, species must “move, adapt, acclimate, or die.” Erik Beever and colleagues review the literature on acclimation through behavioral flexibility, identifying patterns in examples from invertebrates, amphibians, reptiles, birds, mammals, and fishes, in the cover article for the August issue of the Ecological Society of America’s (ESA) journal Frontiers in Ecology and the Environment. The authors focus on the American pika (Ochotona princeps) as a case study in behavioral adaptation.