Researchers have investigated different sensory neural pathways involved in thermoregulation by injecting toxins into parts of the brain involved in ‘feeling’ and responding to temperature changes in the environment. They found that, even upon disabling the pathway for such feeling, rats were able to avoid uncomfortably hot and cold floor plates, but that disabling part of the lateral parabrachial nucleus-mediated pathway led to the loss of this behavior and the loss of core body temperature regulation.