Glaucoma is a serious disease associated with increased intraocular pressure, often leading to blindness. One treatment is to reduce aqueous humour secretion in the ciliary body of the eye by inhibiting the activity of special enzymes called carbonic anhydrases. Russian scientists from RUDN University have designed new compounds that can effectively reduce intraocular pressure by isoform selective inhibiting human carbonic anhydrase. The results of the study have been published in Bioorganic Chemistry.