ESA is preparing for a human mission to Mars via Antarctica and Toulouse.
A human mission to Mars may still be some time away, but scientists are already aware of the many hazards that must be overcome if the dream is to become a reality. One particular cause for concern is the potential for physiological and psychological problems that could arise from the conditions of weightlessness, isolation and confinement experienced during a journey that could last six months or more.
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http://www.esa.int/export/esaCP/SEMOS4T1VED_index_0.html