Researchers from the University of Seville at the Andalusian Centre for Molecular Biology and Regenerative Medicine have discovered that in eukaryotic cells, the proximity of the genes to the pores in the nuclear membrane contributes to maintaining the integrity of the genome. This is due to the fact that the anchoring of DNA to the pore during transcription avoids the formation of DNA-RNA hybrids, which are a natural source of DNA breaks and genome instability.