Brain injuries — whether caused by trauma, tumors, hemorrhage or developmental anomalies — often produce elevated intracranial pressure (ICP), which in turn causes cellular injuries in the brain and additional neurological deficits beyond those associated with the initial insult. Little is known about the mechanisms underlying secondary ICP-induced cellular injuries. Researchers have developed a model of ICP-induced brain injury that could help elucidate those mechanisms and uncover novel therapeutics.