Researchers are assessing clinical and genetic characteristics of a large patient cohort suffering from chronic musculoskeletal pain and receiving prescription opioids. With this information, the multidisciplinary team will derive a clinical and genetic profile of prescription opioid-use disorder and use this knowledge to develop an “addiction risk score.” Findings from this study will be key in identifying those who are at low-risk from those who are at high-risk of prescription opioid-use disorder.