Abstract: The Infrared Spectrograph (IRS) instrument on the Spitzer Space Telescope covered the 5 to 38 micron wavelength range at low and medium spectral resolutions. The instrument was very popular during Spitzers 5.7 year-long cold mission. Every year it attracted the most proposals, and garnered more observing hours, of any of the science instruments. This success was the culmination of a very long development period, where the instrument design changed radically. When the instrument was first sele…